Immunologically Mediated Skin Disorders

Immunologically Mediated Skin Disorders

Urticaria & Angioedema

Urticariais a skin rash that causes red or skin colored bumps that appear and disappear quickly. Urticaria is also known as Hives.

Symptoms of Urticaria:

  • Red or skin colored bumps or lesions
  • Pressing the bump turns it into white
  • They can occur anywhere on the body, change shape, disappear and appear again
urticaria & angioedema treatment


Angioedema develops as a swelling underneath the skin surface and is commonly mistaken for Urticaria. Some of the causes of angioedema include:

  • Allergic reactions
  • Certain Medications
  • Genetic deficiency of certain enzymes

Symptoms of Angioedema:

  • Swelling in the eyes or mouth
  • Swelling of hands, feet, throat
  • Difficulty in Breathing
  • Abdominal cramps

Erythema Nodosum

Erythema Nodosum causes red, painful lumps usually on the shins. It may go away on its own in 3 to 6 weeks. It can leave a bruised appearance.

Causes of Erythema Nodosum

Certain medical conditions linked to erythema nodosum are:

  • Fungal Diseases
  • Strep Throat
  • Cat Scratch Disease
  • Infectious Mononucleosis
  • Inflammatory Bowel Diseases
erythema nodosum tretment

Symptoms of Erythema Nodosum

  • Red, tender bumps
  • Fever
  • Joint Pain
  • Enlarged lymph nodes in the chest

Treatment for Erythema Nodosum depends on the patient’s age, overall health, extent of disease and tolerance for specific medications

Systemic Sclerosis

Systemic Sclerosis, also known as Scleroderma, is a chronic connective tissue disorder that causes abnormalities in blood vessels, skin and internal organs.

Symptoms of systemic sclerosis differ from one person to another. Some of the common symptoms include:

  • Hair loss
  • Calcium Deposits
  • Dilated blood vessels
  • Shortness of breath
  • Abdominal pain
systemic sclerosis treatment

Drug Rash

A skin rash that develops as a result of using certain medications is known as a drug rash. Although any drug can cause an allergic reaction, antibiotics and Non Steroidal Anti Inflammatory Drugs commonly result in skin rashes.

Generally, drug eruptions do not show any symptoms other than their appearance. In some cases, rash may be accompanied by itching and tenderness. Some of the common drug rashes include:

  • Exanthematous rashes featured by raised or flat lesions on the skin. Blisters and pus filled lesions may also appear
  • Urticarial rashes, also known as hives, are the second most common form of drug rash. They develop as pale red bumps
  • Photosensitivity reactions: Some drugs may cause a severe itchy sunburn making you extra sensitive to UV rays.
  • Erythroderma: It makes the entire skin red and itchy. It may also cause your skin to become scaly and a high body temperature.
  • Stevens Johnson Symdrome& Toxic Epidermal Necrolysis: SJS & TEN are serious skin conditions that cause the upper layer of your skin to peel off leaving open sores. It is a life threatening condition and requires immediate attention